DNA methylation, a form of chemical modification of DNA, can effect the genetic expression without changing the DNA sequence. DNA methylation plays an important role in the maintenance of the function of normal cells, inactivation of X chromosome in female, stabilization of genome structure, embryonic development, development and progression of certain diseases such as tumer. EM-seq...

Chromatin Dynamics and Gene Regulation in Eukaryotic Cells The total length of DNA within human cells approximates two meters and necessitates complex folding processes to be accommodated within the nucleus. During this dynamic folding process, chromatin exhibits heterogeneous structural states, manifesting as either open or closed configurations. The open state of chromatin is crucial for the...